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Helicobacter pylori in oral ulcerations
1Department of Oral Surgery, Saitama Medical Center, Saitama Medical School, Kawagoe, Japan.
Journal of Oral Science
|March 28, 2001
Summary
Helicobacter pylori (H. pylori) is not directly linked to most oral ulcers. However, H. pylori may exist in a non-culturable state in the mouth, potentially causing issues during herpes simplex virus (HSV) infections.
Area of Science:
- Oral medicine
- Microbiology
- Infectious diseases
Background:
- Helicobacter pylori (H. pylori) is a known cause of gastrointestinal ulcers.
- Its role in oral ulcerous lesions remains unclear.
- Culture is the gold standard for diagnosing H. pylori infections.
Purpose of the Study:
- To investigate the association between H. pylori and oral mucosal ulcerations.
- To determine if H. pylori plays a direct role in conditions like recurrent aphthous stomatitis (RAS), herpes simplex virus (HSV) stomatitis, and erosive lichen planus (LP).
Main Methods:
- Collected samples from patients with oral mucosal ulcerative disorders.
- Utilized bacterial culture to detect H. pylori.
- Performed serological tests for H. pylori IgG antibodies.
Main Results:
- All recurrent aphthous stomatitis (RAS) and erosive lichen planus (LP) cases were culture-negative for H. pylori.
- Two cases of herpes simplex virus (HSV) stomatitis tested positive for H. pylori via culture.
- These two positive cases also showed seropositivity for H. pylori antigen.
Conclusions:
- H. pylori does not appear to have a direct association with common oral ulcerations like RAS and LP.
- H. pylori may exist in a non-culturable coccoid form in the oral cavity.
- H. pylori might form colonies and contribute to oral issues under specific conditions, such as during HSV infection.