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Updated: Aug 18, 2026
Transurethral Instillation Procedure in Adult Male Mouse
Published on: November 2, 2017
Transurethral alprostadil for the treatment of erectile dysfunction: results of a multicentre trial
1Division of Urology, Department of Surgery, National University Hospital, 5 Lower Kent Ridge Road, Singapore 119704. surlimk@nus.edu.sg
Introduction:
The incidence of erectile dysfunction (ED) has been shown to increase significantly in Singaporean male population. Thus, this prospective study (no controls) assessed the clinical efficacy and safety of a medicated urethral system for erection (MUSE) in Singaporean male patients with a known history of ED.
Subjects And Method:
Eighty-six men with a mean age of 55.7 years with differential causes of ED were administered with MUSE in the clinic with a titration adjustment of 4 possible dose regimes (125, 250, 500 and 1000 mcg) till efficacy is achieved. Subsequently, patients were subjected to home treatment for a duration of 3 months.
Results:
Sixty per cent of inclinic patients exhibited good responses and were given MUSE for home treatment. The efficacy rate for home treatment was 86%. Overall, the patients (n = 86) had a 51.2% success rate in achieving satisfactory sexual intercourse. Diabetic and psychogenic patients were noted to respond well to MUSE. No severe adverse events were found in this study.
Conclusion:
MUSE showed to be a safe, less invasive, well-tolerated and efficient alternative treatment for ED in Singaporean men.
