Related Experiment Video
Updated: Aug 13, 2026

07:36
Isolation of Human Lymphatic Endothelial Cells by Multi-parameter Fluorescence-activated Cell Sorting
Published on: May 1, 2015
Lymphangioma circumscriptum of the vulva
J I Esquivias Gómez1, A Miranda-Romero, C Cuadrado Vallés
1Dermatology Department, University Hospital of Valladolid, Spain.
Cutis
|March 29, 2001
Summary
Lymphangioma circumscriptum, a rare vulvar lesion, may be caused by chronic lymphedema. This case report suggests a link between lower limb lymphedema and vulvar lymphangioma circumscriptum development.
Area of Science:
- Dermatology
- Pathology
- Vascular Medicine
Background:
- Lymphangioma circumscriptum is a rare benign condition affecting lymphatic vessels.
- Its etiology is often unclear, with lymphatic obstruction proposed as a potential cause.
- Vulvar involvement is particularly uncommon.
Observation:
- A 44-year-old woman presented with vulvar lesions resembling lymphangioma circumscriptum.
- The patient also had a history of chronic idiopathic lymphedema of the lower right limb.
- No other apparent cause for the vulvar lesions was identified.
Findings:
- The case suggests a potential causal link between chronic lymphedema and the development of lymphangioma circumscriptum.
- The vulvar lymphangioma circumscriptum may have arisen secondary to lymphatic obstruction caused by the limb lymphedema.
Implications:
- This case highlights a possible etiology for vulvar lymphangioma circumscriptum.
- Understanding this association may aid in diagnosis and management of similar cases.
- Further research into the relationship between lymphedema and lymphangioma circumscriptum is warranted.
More Related Videos
Related Concept Videos
Lymphatic Vessels and Lymph Transport
Lymphatic vessels, known as lymphatics, are crucial in transporting lymph from peripheral tissues to our venous system. This process begins with lymph entering through tiny capillaries that branch through tissues. These capillaries have unique features such as larger diameters, thinner walls, and a distinctive one-way valve system formed by overlapping endothelial cells.
This one-way system allows fluids, solutes, and even pathogens to enter but prevents their return to the intercellular spaces.
This one-way system allows fluids, solutes, and even pathogens to enter but prevents their return to the intercellular spaces.
Development of the Lymphatic System
The development of lymphatic tissues and vessels in embryonic life begins around the fifth week. These structures originate from the mesoderm layer, with lymph sacs emerging from developing veins.
The first lymph sacs to form are the paired jugular lymph sacs located at the junction of the internal jugular and subclavian veins. From these sacs, lymphatic capillary plexuses extend to the thorax, upper limbs, neck, and head, eventually forming lymphatic vessels. Each jugular lymph sac maintains a...
The first lymph sacs to form are the paired jugular lymph sacs located at the junction of the internal jugular and subclavian veins. From these sacs, lymphatic capillary plexuses extend to the thorax, upper limbs, neck, and head, eventually forming lymphatic vessels. Each jugular lymph sac maintains a...

