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[Sodium valproate-induced kinky hair]
S Caneppele1, J Mazereeuw-Hautier, J L Bonafé
1Service de Dermatologie, Hôpital Rangueil, Toulouse.
Annales De Dermatologie Et De Venereologie
|March 29, 2001
Summary
Sodium valproate, a medication, can cause acquired progressive kinking hair syndrome, a rare hair disorder. This is the first reported case linking this drug to the condition.
Area of Science:
- Dermatology
- Pediatrics
- Pharmacology
Background:
- Acquired progressive kinking hair syndrome is a rare pilar dysplasia.
- Drug-induced hair abnormalities are uncommon but clinically significant.
Observation:
- A 6-year-old girl developed kinky, lusterless, and dry hair.
- Hair changes were progressive and consistent with pseudo-pili torti on microscopy.
Findings:
- This case represents the first instance of sodium valproate-induced acquired progressive kinking hair syndrome.
- Previous reports noted valproate-induced pilar dysplasia without detailed clinical descriptions.
Implications:
- Sodium valproate should be considered a potential cause of kinky hair syndrome.
- Clinicians should be aware of this adverse effect when prescribing sodium valproate, especially in pediatric patients.