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Related Experiment Videos

Methodology of brain perfusion imaging.

E L Barbier1, L Lamalle, M Décorps

  • 1Laboratoire mixte INSERM U438, Université Joseph Fourier: RMN Bioclinique, LRC-CEA, Hôpital Albert Michallon, Grenoble, France.

Journal of Magnetic Resonance Imaging : JMRI
|March 29, 2001
PubMed
Summary

This review covers magnetic resonance imaging (MRI) methods for measuring brain blood volume (CBV) and flow (CBF). It details techniques like contrast agents and arterial spin labeling (ASL), discussing their potential and limitations.

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Area of Science:

  • Neuroimaging
  • Medical Physics
  • Radiology

Background:

  • Brain perfusion measurement is crucial for understanding neurological function and disease.
  • Over the past 15 years, significant advancements have been made in quantifying brain perfusion parameters.
  • Two prominent MRI-based techniques, contrast agent-based cerebral blood volume (CBV) measurement and arterial spin labeling (ASL) for cerebral blood flow (CBF) assessment, have emerged as highly effective.

Purpose of the Study:

  • To review the methodologies of various MRI techniques used for measuring CBV and CBF.
  • To provide an overview of the current state of brain perfusion imaging.
  • To discuss the limitations and future potential of these MRI techniques.

Main Methods:

  • Detailed explanation of MRI techniques for CBV measurement using paramagnetic contrast agents.

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  • Comprehensive description of arterial spin labeling (ASL) principles and applications for CBF quantification.
  • Comparative analysis of the strengths and weaknesses of different perfusion MRI methods.

    • Main Results:

    • Paramagnetic contrast agents offer robust CBV measurement capabilities.
    • Arterial spin labeling (ASL) provides non-invasive CBF quantification.
    • Both techniques have specific advantages and limitations influencing their clinical and research applications.

    Conclusions:

    • MRI offers powerful tools for assessing brain perfusion, with contrast-enhanced CBV and ASL-based CBF being leading methods.
    • Understanding the methodologies, limitations, and potentials of these techniques is vital for accurate brain perfusion assessment.
    • Continued development in MRI technology promises further improvements in the precision and applicability of brain perfusion measurements.