Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Fibroblast growth factors.

D M Ornitz1, N Itoh

  • 1Department of Molecular Biology and Pharmacology, Washington University Medical School, 660 S. Euclid Avenue, St. Louis, MO 63110, USA. dornitz@molecool.wustl.edu

Genome Biology
|March 29, 2001
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Mice with conditional inactivation of fibroblast growth factor receptor-2 signaling in oligodendrocytes have normal myelin but display dramatic hyperactivity when combined with Cnp1 inactivation.

The Journal of neuroscience : the official journal of the Society for Neuroscience·2006
Same author

Patterning the optic neuroepithelium by FGF signaling and Ras activation.

Development (Cambridge, England)·2001
Same author

Development and maintenance of otoconia: biochemical considerations.

Annals of the New York Academy of Sciences·2001
Same author

Physical mapping of the mouse tilted locus identifies an association between human deafness loci DFNA6/14 and vestibular system development.

Genomics·2001
Same author

Differential regulation of endochondral bone growth and joint development by FGFR1 and FGFR3 tyrosine kinase domains.

Development (Cambridge, England)·2001
Same author

Lung hypoplasia and neonatal death in Fgf9-null mice identify this gene as an essential regulator of lung mesenchyme.

Development (Cambridge, England)·2001

Fibroblast growth factors (FGFs) are vital proteins regulating cell growth and repair across species. Dysregulation of FGFs can lead to cancer, while some are crucial for nerve signaling.

Area of Science:

  • Molecular Biology
  • Developmental Biology
  • Biochemistry

Background:

  • Fibroblast growth factors (FGFs) comprise a large family of conserved polypeptide growth factors.
  • They are essential in embryonic development, controlling cell proliferation, migration, and differentiation.
  • FGFs also play critical roles in adult tissue repair and homeostasis.

Purpose of the Study:

  • To summarize the diverse roles of Fibroblast Growth Factors (FGFs).
  • To highlight their importance in embryonic development and adult tissue function.
  • To discuss their involvement in disease pathogenesis and neuronal signaling.

Main Methods:

  • Review of existing literature on FGF family.
  • Analysis of FGF conservation across species.

Related Experiment Videos

  • Examination of FGF interactions with heparan sulfate and receptors.

    • Main Results:

    • FGFs are highly conserved across vertebrate species, with 22 members identified.
    • They bind heparan sulfate proteoglycans to activate FGF receptors.
    • FGFs are crucial for embryonic development, tissue repair, and neuronal signaling.

    Conclusions:

    • FGFs are fundamental regulators of cellular processes from development to adulthood.
    • Aberrant FGF expression is implicated in cancer development.
    • Specific FGFs are vital for signal transduction in the nervous system.