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Synthesis and antitumor activity of novel paclitaxel-chlorambucil hybrids
M D Wittman1, J F Kadow, D M Vyas
1Discovery Chemistry, Bristol-Myers Squibb Pharmaceutical Research Institute, Wallingford, CT 06492-7660, USA. mark.wittman@bms.com
Bioorganic & Medicinal Chemistry Letters
|March 30, 2001
Abstract:
The syntheses and antitumor activity of three paclitaxel-chlorambucil hybrids are presented. Hybrid 3 showed significant in vivo efficacy.