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N-Aminoindoline derivatives as inhibitors of 5-lipoxygenase
C Audouin1, N Mestdagh, M A Lassoie
1Institut de Chimie Pharmaceutique Albert Lespagnol, Université de Lille 2, France.
Bioorganic & Medicinal Chemistry Letters
|March 30, 2001
Abstract:
N-Aminoindoline derivatives were prepared and their 5-lipoxygenase inhibitory activities were evaluated in vitro and compared with those of phenidone and NDGA. Compound 4 presents the most effective 5-LO inhibition.