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Synthesis of (+)-cyclozonarone and the absolute configuration of naturally occurring (-)-cyclozonarone
M Cortés1, J A Valderrama, M Cuellar
1Facultad de Química, Pontificia Universidad Católica de Chile, Casilla 306, Correo 22, Santiago, Chile. mcortesm@puc.cl
Journal of Natural Products
|March 30, 2001
Abstract:
Synthesis of (+)-cyclozonarone (1) has been achieved using (-)-polygodial (3) as chiral starting material. The absolute configuration of naturally occurring (-)-cyclozonarone was established as 5R,10R by comparison of spectral data and optical rotation with those of (+)-cyclozonarone.