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Post-transplant lymphoproliferative disease in tonsils of children with liver transplantation

J I De Diego1, M P Prim, D Hardisson

  • 1Department of Otorhinolaryngology, La Paz Hospital, Autonomous University of Madrid, Madrid, Spain. jidediegompprim@retemail.es

International Journal of Pediatric Otorhinolaryngology
|March 30, 2001
PubMed

Insights

Post-transplant lymphoproliferative disease (PTLD) in pediatric liver transplant recipients is rare, with tonsillar involvement occurring in only 1.4% of cases. Early diagnosis through careful follow-up is crucial for allograft recipients.

Area of Science:

  • Pediatric Gastroenterology
  • Transplant Surgery
  • Oncology

Background:

  • Post-transplant lymphoproliferative disease (PTLD) is a serious complication following organ transplantation.
  • Tonsillar PTLD is a rare manifestation, particularly in pediatric liver transplant recipients.

Purpose of the Study:

  • To determine the incidence and characteristics of PTLD in the tonsils of children who have undergone liver transplantation.
  • To evaluate the diagnostic approach for suspected tonsillar PTLD in this population.

Main Methods:

  • Retrospective analysis of pediatric liver transplant recipients under 14 years of age.
  • Inclusion of patients who underwent tonsillectomy due to suspicion of malignancy.
  • Histopathological examination of tonsillar tissue for PTLD diagnosis.

Main Results:

  • Seven pediatric liver transplant recipients underwent tonsillectomy for suspected PTLD.
  • PTLD was diagnosed in four patients: one B-cell lymphoma and three polymorphic diffuse B-cell hyperplasia.
  • The incidence of tonsillar PTLD was 1.4% among 283 pediatric liver transplants.

Conclusions:

  • The incidence of PTLD in the tonsils of pediatric liver transplant recipients at this institution is very low.
  • Despite low incidence, vigilant follow-up of allograft recipients is essential for early detection and management of PTLD.
Abstract

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