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Updated: Aug 13, 2026

Mutagenesis and Functional Selection Protocols for Directed Evolution of Proteins in E. coli
Published on: March 16, 2011
Second-order selection in bacterial evolution: selection acting on mutation and recombination rates in the course of
O Tenaillon1, F Taddei, M Radmian
1Inserm E9916, Faculté de médecine Necker Enfants Malades, Université Paris V, France. tenaillo@necker.fr
Abstract:
The increase in genetic variability of a population can be selected during adaptation, as demonstrated by the selection of mutator alleles. The dynamics of this phenomenon, named second-order selection, can result in an improved adaptability of bacteria through regulation of all facets of mutation and recombination processes.
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