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Related Experiment Video

Updated: Jul 25, 2026

Use of Rabbit Eyes in Pharmacokinetic Studies of Intraocular Drugs

Use of Rabbit Eyes in Pharmacokinetic Studies of Intraocular Drugs

Published on: July 23, 2016

Systemic corticosteroid use in orbital lymphangioma.

B S Sires¹, C R Goins, R L Anderson

¹Department of Ophthalmology, University of Washington, Seattle 98195-6485, USA.

Ophthalmic Plastic and Reconstructive Surgery

|April 3, 2001

Summary

Systemic corticosteroids offer a beneficial treatment for orbital lymphangioma, improving symptoms in both adults and children. This therapy can expedite symptom resolution, serving as a valuable addition to existing treatments.

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Area of Science:

Ophthalmology
Pediatric Ophthalmology
Vascular Malformations

Background:

Orbital lymphangioma is a congenital vascular malformation causing significant morbidity.
Treatment options for orbital lymphangioma are limited and often invasive.

Observation:

Four patients with orbital lymphangioma (two adults, two children) received systemic corticosteroid therapy.
Treatment duration varied from 2 days to 1 month, utilizing intravenous and/or oral routes.
Corticosteroids were administered alone or as an adjunct to other therapies during symptomatic exacerbations.

Findings:

Adult patients experienced greater relief from pain than swelling.
Pediatric patients showed improvement in both signs and symptoms.
No adverse complications were reported in any of the patients during the study period.

Implications:

Systemic corticosteroids represent a viable therapeutic strategy for managing orbital lymphangioma.
Corticosteroid therapy can accelerate symptom resolution compared to the natural disease course.
This approach may serve as an effective adjuvant treatment alongside surgery and other modalities for orbital lymphangioma.