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Use of Rabbit Eyes in Pharmacokinetic Studies of Intraocular Drugs
Published on: July 23, 2016
Systemic corticosteroid use in orbital lymphangioma
B S Sires1, C R Goins, R L Anderson
1Department of Ophthalmology, University of Washington, Seattle 98195-6485, USA.
Ophthalmic Plastic and Reconstructive Surgery
|April 3, 2001
Summary
Systemic corticosteroids offer a beneficial treatment for orbital lymphangioma, improving symptoms in both adults and children. This therapy can expedite symptom resolution, serving as a valuable addition to existing treatments.
Area of Science:
- Ophthalmology
- Pediatric Ophthalmology
- Vascular Malformations
Background:
- Orbital lymphangioma is a congenital vascular malformation causing significant morbidity.
- Treatment options for orbital lymphangioma are limited and often invasive.
Observation:
- Four patients with orbital lymphangioma (two adults, two children) received systemic corticosteroid therapy.
- Treatment duration varied from 2 days to 1 month, utilizing intravenous and/or oral routes.
- Corticosteroids were administered alone or as an adjunct to other therapies during symptomatic exacerbations.
Findings:
- Adult patients experienced greater relief from pain than swelling.
- Pediatric patients showed improvement in both signs and symptoms.
- No adverse complications were reported in any of the patients during the study period.
Implications:
- Systemic corticosteroids represent a viable therapeutic strategy for managing orbital lymphangioma.
- Corticosteroid therapy can accelerate symptom resolution compared to the natural disease course.
- This approach may serve as an effective adjuvant treatment alongside surgery and other modalities for orbital lymphangioma.
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