Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Dynamic combinatorial chemistry.

I Huc1, R Nguyen

  • 1IECB -- Polytechnique, ENSCPB av. Pey Berland, 33402 Talence Cedex, France. ivan.huc@iecb-polytechnique.u-bordeaux.fr

Combinatorial Chemistry & High Throughput Screening
|April 3, 2001
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

PhotoSENSIL-18 assay development: Enhancing the safety testing of cosmetic raw materials and finished products to support the in vitro photosensitization assessment?

Toxicology·2023
Same author

Ocular conjunctivitis in biological therapies for atopic dermatitis.

The British journal of dermatology·2022
Same author

Solid Phase Synthesis of Helically Folded Aromatic Oligoamides.

Methods in enzymology·2016
Same author

Withdrawn: An unusual urticarial eruption: familial cold autoinflammatory syndrome.

Australian dental journal·2015
Same author

Core-shell inversion by pH modulation in dynamic covalent micelles.

Soft matter·2014
Same author

Cardiac characterization of 16 patients with large NF1 gene deletions.

Clinical genetics·2013
Same journal

Exploring Spectral Graph Theory in Combinatorial Chemistry.

Combinatorial chemistry & high throughput screening·2026
Same journal

Unveiling the Cellular and Molecular Insights into Ulcerative Colitis Pathogenesis through Integrative Multi-omics and Functional Experiments.

Combinatorial chemistry & high throughput screening·2026
Same journal

Integrated Multi-Omics Identification of Novel Diagnostic Biomarkers and Immunometabolic Therapeutic Targets in Osteoporosis via Machine Learning.

Combinatorial chemistry & high throughput screening·2026
Same journal

Exploration and Prospects of Core Research Hotspots in the Mechanisms of Traditional Chinese Medicine for Treating Digestive System Malignancies Based on Bibliometrics.

Combinatorial chemistry & high throughput screening·2026
Same journal

Investigating the Potential Pharmacological Mechanisms of Huangqi in Allergic Rhinitis Using Network Pharmacology and Molecular Docking Strategies.

Combinatorial chemistry & high throughput screening·2026
Same journal

DNMT3A-driven Clonal Expansion of Hematopoiesis Influences Autoimmunity Mediated by Distinct Immune Cell Populations: A Mendelian Randomization Study.

Combinatorial chemistry & high throughput screening·2026
See all related articles

Dynamic combinatorial chemistry utilizes reversible reactions to create molecular libraries for identifying target molecule binders. This review covers applications and practical implementation of this powerful chemical strategy.

Area of Science:

  • Chemistry
  • Biochemistry

Background:

  • Dynamic combinatorial chemistry (DCC) involves reversible reactions of building blocks to form dynamic combinatorial libraries (DCLs).
  • DCC has emerged as a key strategy for detecting and evaluating molecular interactions with target molecules.

Purpose of the Study:

  • To review the diverse applications of DCC across chemistry and biochemistry.
  • To discuss the practical considerations for implementing DCC approaches.

Main Methods:

  • Literature review of DCC applications.
  • Analysis of case studies from various scientific fields.

Main Results:

  • DCC is effective for affinity screening and lead discovery.
  • Examples demonstrate successful application in drug discovery and chemical biology.

Related Experiment Videos

Conclusions:

  • DCC offers a versatile and efficient platform for molecular recognition studies.
  • Practical implementation guidance is provided for researchers.