Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Glial control of neuronal development.

G Lemke1

  • 1Molecular Neurobiology Laboratory, The Salk Institute, La Jolla, California 92037, USA. lemke@salk.edu

Annual Review of Neuroscience
|April 3, 2001
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Mer receptor tyrosine kinase mediates both tethering and phagocytosis of apoptotic cells.

Cell death & disease·2015
Same author

Insertional mutation at the ld locus (again!) in a line of transgenic mice.

Mouse genome·2014
Same author

Homeostatic regulation of the immune system by receptor tyrosine kinases of the Tyro 3 family.

Science (New York, N.Y.)·2001
Same author

The collagen receptor DDR2 regulates proliferation and its elimination leads to dwarfism.

EMBO reports·2001
Same author

Topographic mapping from the retina to the midbrain is controlled by relative but not absolute levels of EphA receptor signaling.

Cell·2000
Same author

Induction of postnatal schwann cell death by the low-affinity neurotrophin receptor in vitro and after axotomy.

The Journal of neuroscience : the official journal of the Society for Neuroscience·2000
Same journal

Body-Brain Integration: The Lower Brainstem in Sleep-Wake Regulation.

Annual review of neuroscience·2026
Same journal

Planning in the Brain: It's Not What You Think It Is.

Annual review of neuroscience·2026
Same journal

The Emerging Neurobiology of Psychedelics: Critical Periods, Metaplasticity, and Extracellular Matrix Remodeling.

Annual review of neuroscience·2026
Same journal

Rethinking Predictive Processing.

Annual review of neuroscience·2026
Same journal

Path Integration in Alzheimer's Disease: Orientation, Movement, and Theta Rhythmicity.

Annual review of neuroscience·2026
Same journal

The Cellular and Circuit Basis of Temperature Sensation in <i>Drosophila</i>.

Annual review of neuroscience·2026
See all related articles

Nervous system development relies on reciprocal signaling between developing neurons and glial cells. This essential, interdependent communication guides cell survival, fate commitment, and axon guidance for proper neural network formation.

Area of Science:

  • Neuroscience
  • Developmental Biology
  • Cell Biology

Background:

  • Glial cells and neurons engage in critical reciprocal signaling during nervous system development.
  • This interaction is vital even before cell types are fully differentiated.
  • Glial cells influence neuronal survival, contingent on neuronal signals for glial fate and growth factor production.

Purpose of the Study:

  • To elucidate the fundamental principles of reciprocal signaling between developing neurons and glia.
  • To highlight the roles of specific signaling pathways and molecules in this interactive process.
  • To emphasize the interdependent nature of neuronal and glial communication in establishing neural networks.

Main Methods:

  • Comparative analysis across model organisms (Drosophila, mammals).

Related Experiment Videos

  • Investigation of key molecular players like neuregulin-1 and ErbB receptors.
  • Examination of glial factors involved in axon guidance (netrin, slit) and transcription factors.

    • Main Results:

    • Glial cell-mediated neuronal survival is dependent on prior neuronal signaling.
    • Neuregulin-1/ErbB signaling is crucial for glial fate and trophic factor expression in mammals.
    • Glial cues and transcription factors regulate pioneer axon guidance at the neural midline.

    Conclusions:

    • Reciprocal signaling is a defining principle in nervous system development.
    • Mutually reinforced and dependent signaling networks between neurons and glia are essential.
    • This interactive communication underpins the formation of functional neural connections.