Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Estrogens decrease reperfusion-associated cortical ischemic damage: an MRI analysis in a transient focal ischemia

J Shi1, J D Bui, S H Yang

  • 1Departments of Pharmacodynamics, University of Florida Brain Institute, Tallahassee, Florida, USA.

Stroke
|April 3, 2001
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

The Variable Appearance of Third Ventricular Colloid Cysts: Correlation with Histopathology and the Risk of Obstructive Ventriculomegaly.

AJNR. American journal of neuroradiology·2020
Same author

Effect of cell density and HLA-DR incompatibility on T-cell proliferation and forkhead box P3 expression in human mixed lymphocyte reaction.

Transplantation proceedings·2015
Same author

Establishment of the National Cancer Research Institute Clinical and Translational Radiotherapy Research Working Group (CTRad) Biomarker Support Network.

Clinical oncology (Royal College of Radiologists (Great Britain))·2014
Same author

The effects of cryoablation on renal cell carcinoma perfusion and glomerular filtration rate measured using dynamic contrast-enhanced MRI: a feasibility study.

Clinical radiology·2013
Same author

Imaging vascular function for early stage clinical trials using dynamic contrast-enhanced magnetic resonance imaging.

European radiology·2012
Same author

Tracer kinetic modelling in MRI: estimating perfusion and capillary permeability.

Physics in medicine and biology·2011
Same journal

Management of Patients at Risk of Ischemic Stroke With Left Ventricular Systolic Dysfunction in the Absence of Intracardiac Thrombus: A Scientific Statement From the American Heart Association.

Stroke·2026
Same journal

Update on Rehabilitation After Stroke: Global Changes and the Continued Importance of Therapy Intensity, Dose, and Timing.

Stroke·2026
Same journal

ENTF Neuromodulation Yields Reduced Disability After Stroke: An Individual Participant-Level Data Meta-Analysis.

Stroke·2026
Same journal

Menopause and Its Implications for Stroke in Women.

Stroke·2026
Same journal

Physician Approaches to Determining Goals of Stroke Care for Patients Living With Disability or Dementia: Results from the SEED Mixed-Methods Study.

Stroke·2026
Same journal

Aspirin for Stroke Primary Prevention: A Step Toward Genetic-Driven Personalized Medicine.

Stroke·2026
See all related articles

Estrogen replacement therapy significantly reduced ischemic stroke damage in female rats, particularly in cortical areas. This neuroprotection occurred during both occlusion and reperfusion without altering cerebral blood flow.

Area of Science:

  • Neuroscience
  • Stroke Research
  • Endocrinology

Background:

  • Early identification of irreversible cerebral ischemia is crucial for stroke management and neuronal survival.
  • 17beta-estradiol (E2) effects on focal ischemia temporal evolution require investigation.

Purpose of the Study:

  • To investigate the effects of 17beta-estradiol (E2) on the temporal evolution of focal cerebral ischemia using MRI.
  • To determine if estrogen replacement influences neuronal survival after stroke.

Main Methods:

  • Female rats underwent ovariectomy, with one group receiving estrogen replacement (OVX+E2) and the other not (OVX).
  • Both groups were subjected to middle cerebral artery occlusion (MCAO) followed by reperfusion.
  • Sequential diffusion-weighted (DWI) and T2-weighted (T2WI) MRI were used to assess lesion evolution, and cerebral blood flow (CBF) was measured.

Related Experiment Videos

Main Results:

  • Estrogen replacement (OVX+E2) led to a 50-60% reduction in DWI lesion size during reperfusion, primarily in cortical regions.
  • Estrogen treatment attenuated signal intensity ratios during MCAO and reperfusion in cortical areas.
  • No significant differences in cerebral blood flow (CBF) were observed between groups during occlusion or reperfusion.

Conclusions:

  • Estrogens selectively protect cortical tissue from ischemic damage during MCAO, impacting both occlusion and reperfusion phases.
  • This neuroprotective effect of estrogen does not appear to be mediated by changes in cerebral blood flow.
  • Findings suggest a potential therapeutic role for estrogens in stroke recovery.