Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Video

Updated: Jul 27, 2026

The bm12 Inducible Model of Systemic Lupus Erythematosus (SLE) in C57BL/6 Mice
12:04

The bm12 Inducible Model of Systemic Lupus Erythematosus (SLE) in C57BL/6 Mice

Published on: November 1, 2015

Lupus nephritis: lessons from experimental animal models.

C J Peutz-Kootstra1, E de Heer, P J Hoedemaeker

  • 1Department of Pathology, Utrecht University Medical Center, Utrecht, The Netherlands.

The Journal of Laboratory and Clinical Medicine
|April 3, 2001
PubMed
Summary

Animal models reveal the immunopathology of lupus nephritis, a severe lupus complication. This review synthesizes current knowledge and proposes a hypothetical pathway for disease development, linking experimental findings to human lupus.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

The relationship of peritubular capillary density with glomerular volume and kidney function in living kidney donors.

Journal of nephrology·2023
Same author

Carnosinase Gene-Is It Responsible for Diabetic Nephropathy?: Carnosine as a Protective Factor in Diabetic Nephropathy: Association with a Leucine Repeat of the Carnosinase Gene CNDP1. Diabetes 54: 2320-2327, 2005.

Journal of the American Society of Nephrology : JASN·2023
Same author

Rapid Identification of Ischemic Injury in Renal Tissue by Mass-Spectrometry Imaging.

Analytical chemistry·2019
Same author

Towards standardized criteria for diagnosing chronic intervillositis of unknown etiology: A systematic review.

Placenta·2017
Same author

Stability and Species Specificity of Renal VEGF-A Splicing Patterns in Kidney Disease.

PloS one·2016
Same author

The use of thyroid hormone in the treatment of depression: a review.

Acta neuropsychiatrica·2016

Area of Science:

  • Immunopathology
  • Autoimmune Diseases
  • Nephrology

Background:

  • Lupus nephritis is a severe complication of Systemic Lupus Erythematosus (SLE).
  • Animal models are crucial for studying SLE immunopathology before clinical manifestation.
  • Understanding disease mechanisms in preclinical models aids therapeutic development.

Purpose of the Study:

  • To review current knowledge on lupus nephritis development using animal models.
  • To postulate a hypothetical pathway for lupus nephritis pathogenesis.
  • To discuss the relevance of animal model studies to human SLE.

Main Methods:

  • Literature review of studies on animal models of SLE.
  • Synthesis of data on lupus nephritis development in experimental models.

More Related Videos

A Mouse 5/6th Nephrectomy Model That Induces Experimental Uremic Cardiomyopathy
07:52

A Mouse 5/6th Nephrectomy Model That Induces Experimental Uremic Cardiomyopathy

Published on: November 7, 2017

Analyses of Proteinuria, Renal Infiltration of Leukocytes, and Renal Deposition of Proteins in Lupus-prone MRL/lpr Mice
09:43

Analyses of Proteinuria, Renal Infiltration of Leukocytes, and Renal Deposition of Proteins in Lupus-prone MRL/lpr Mice

Published on: June 8, 2022

Related Experiment Videos

Last Updated: Jul 27, 2026

The bm12 Inducible Model of Systemic Lupus Erythematosus (SLE) in C57BL/6 Mice
12:04

The bm12 Inducible Model of Systemic Lupus Erythematosus (SLE) in C57BL/6 Mice

Published on: November 1, 2015

A Mouse 5/6th Nephrectomy Model That Induces Experimental Uremic Cardiomyopathy
07:52

A Mouse 5/6th Nephrectomy Model That Induces Experimental Uremic Cardiomyopathy

Published on: November 7, 2017

Analyses of Proteinuria, Renal Infiltration of Leukocytes, and Renal Deposition of Proteins in Lupus-prone MRL/lpr Mice
09:43

Analyses of Proteinuria, Renal Infiltration of Leukocytes, and Renal Deposition of Proteins in Lupus-prone MRL/lpr Mice

Published on: June 8, 2022

  • Postulation of a hypothetical pathogenic pathway.

    • Main Results:

    • Animal models provide insights into the early immunopathological events of lupus nephritis.
    • A hypothetical pathway for lupus nephritis development is proposed based on experimental data.
    • The translational relevance of animal studies to human SLE is highlighted.

    Conclusions:

    • Animal models are invaluable for dissecting the complex pathogenesis of lupus nephritis.
    • The proposed hypothetical pathway offers a framework for understanding disease progression.
    • Further research integrating animal model findings with human SLE data is warranted.