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Sporadic neonatal schizencephaly associated with brain calcification
A M al-Alawi1, K I al-Tawil, M M al-Hathal
1Department of Pediatrics (Neonatology Division), King Fahad National Guard Hospital, Riyadh, Saudi Arabia. tawil1954@yahoo.com
Annals of Tropical Paediatrics
|April 4, 2001
Summary
This case study highlights a rare neonatal presentation of schizencephaly. The infant experienced seizures and developmental delays, emphasizing the importance of early diagnosis in congenital brain malformations.
Area of Science:
- Neurology
- Developmental Biology
- Pediatrics
Background:
- Schizencephaly is a rare congenital brain malformation characterized by clefts in the cerebral hemispheres.
- Neonatal presentation of schizencephaly is uncommon, often diagnosed later in infancy or childhood.
Observation:
- A neonate presented with intrauterine growth retardation and microcephaly.
- Seizures developed on the third day of life.
- No evidence of congenital viral infection was found clinically or in laboratory tests.
Findings:
- Brain imaging revealed diffuse intracranial calcifications and bilateral schizencephaly.
- By 11 months of age, the infant exhibited severe psychomotor retardation.
Implications:
- This case underscores the possibility of rare neonatal presentations of schizencephaly.
- Early identification of brain malformations like schizencephaly is crucial for timely intervention and management.
- Further research into the etiology and early diagnostic markers for neonatal schizencephaly is warranted.