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Published on: October 14, 2015
[Oral contraceptive and breast cancer: a case-control study]
S Tessaro1, J U Béria, E Tomasi
1Departamento Materno-Infantil, Faculdade de Medicina, Universidade Federal de Pelotas, Pelotas, RS, Brasil. tessaro.sul@zaz.com.br
This study found no general link between oral contraceptive use and breast cancer. However, a near-significant increased risk was observed in women over 45 using oral contraceptives for over five years.
Area of Science:
- Epidemiology
- Oncology
- Reproductive Health
Context:
- Breast cancer is a significant global health concern.
- Oral contraceptive (OC) use is widespread among women of reproductive age.
- Understanding potential risk factors for breast cancer is crucial for public health initiatives.
Purpose:
- To investigate the association between breast cancer and oral contraceptive (OC) use, including duration and age of initiation.
- To analyze this association in a population-based study in Pelotas, Southern Brazil.
Summary:
- A case-control study involving 250 breast cancer cases and 1020 controls was conducted.
- No overall association was found between OC use and breast cancer.
- A trend towards increased risk was observed in women over 45 using OCs for five or more years (OR=1.6, p=0.05).
Impact:
- Findings suggest that long-term oral contraceptive use in older women may warrant further investigation as a potential risk factor.
- This research contributes to the ongoing discussion on the safety of oral contraceptives and breast cancer risk.
- Results can inform clinical guidelines and public health messaging regarding oral contraceptive use and breast cancer prevention.
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