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Tumor Transplantation for Assessing the Dynamics of Tumor-Infiltrating CD8+ T Cells in Mice
Published on: June 12, 2021
A symbiotic concept of autoimmunity and tumour immunity: lessons from vitiligo
P K Das1, R M van den Wijngaard, A Wankowicz-Kalinska
1Department of Pathology, Academic Medical Centre, Amsterdam University, Meibergdreef 9, 1105 AZ, Amsterdam, The Netherlands. p.k.das@amc.uva.nl
Abstract:
Vitiligo is a skin disease in which melanocytes (MCs) are eradicated from lesional epidermis, resulting in disfiguring loss of pigment. MCs are destroyed by MC-reactive T cells, as well as other non-immune and immune components. Similarities exist between the autoimmunity observed in vitiligo and the tumour immunity observed in melanoma immuno-surveillance. An analysis of these mechanisms might lead to the development of new therapies for both vitiligo and melanoma.
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