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Dissecting Host-virus Interaction in Lytic Replication of a Model Herpesvirus
11:28

Dissecting Host-virus Interaction in Lytic Replication of a Model Herpesvirus

Published on: October 7, 2011

Disease model: dissecting the pathogenesis of the measles virus

J B Patterson1, M Manchester, M B Oldstone

  • 1Division of Virology, Dept of Neuropharmacology, The Scripps Research Institute, 10550 N. Torrey Pines Rd, La Jolla, CA 92037, USA.

Trends in Molecular Medicine
|April 5, 2001
PubMed

Insights

Measles virus (MV) pathogenesis remains unclear. New CD46 transgenic mouse models allow studying MV infection of the brain and immune system, revealing viral and host factors in disease.

Area of Science:

  • Virology
  • Immunology
  • Neuroscience

Background:

  • Measles virus (MV) is a major global cause of childhood mortality.
  • Understanding MV host-pathogen interactions, particularly in the central nervous system (CNS) and immune system, is crucial but limited.
  • Existing models do not fully recapitulate the complex pathogenesis of MV infection.

Purpose of the Study:

  • To develop and utilize transgenic mouse models for studying MV pathogenesis.
  • To investigate MV infection within the CNS and its impact on the immune system.
  • To elucidate the roles of viral and host factors in measles disease.

Main Methods:

  • Generation of transgenic mice expressing the human measles virus receptor, CD46.
  • Infection of CD46 transgenic mice with MV to model CNS and immune system pathology.
  • Integration of mouse knockout technology and recombinant MV systems for comprehensive analysis.

Main Results:

  • CD46 transgenic mice successfully model MV infection of the CNS, showing neuronal replication and spread.
  • Observed inflammation and mortality in the CNS-infected mice, mirroring severe measles cases.
  • Demonstrated the utility of these models for studying MV-induced immunosuppression.

Conclusions:

  • CD46 transgenic mice provide valuable models for investigating measles virus pathogenesis.
  • These models facilitate the study of MV's effects on the CNS and immune system.
  • Future research with these models will enhance understanding of viral and host contributions to measles disease.

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