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Expression of a novel mammalian epidermal growth factor-related gene during mouse neural development

S Grimmond1, R Larder, N Van Hateren

  • 1MRC Mammalian Genetics Unit, Harwell, OX11 0RD, Didcot, UK.

Mechanisms of Development
|April 5, 2001
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Determination01:51

Determination

During embryogenesis, cells become progressively committed to different fates through a two-step process: specification followed by determination. Specification is demonstrated by removing a segment of an early embryo, “neutrally” culturing the tissue in vitro—for example, in a petri dish with simple medium—and then observing the derivatives. If the cultured region gives rise to cell types that it would normally generate in the embryo, this means that it is specified. In contrast, determination...