Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Does surface chemistry affect thrombogenicity of surface modified polymers?

M V Sefton1, A Sawyer, M Gorbet

  • 1Department of Chemical Engineering and Applied Chemistry, Institute for Biomaterials and Biomedical Engineering, University of Toronto, Toronto, Ontario, Canada M5S 3G9.

Journal of Biomedical Materials Research
|April 5, 2001
PubMed
Summary

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Response to Letter to the Editor: "Early Childhood Exposures to Fluorides and Cognitive Neurodevelopment: A Population-Based Longitudinal Study".

Journal of dental research·2025
Same author

Unveiling the social and environmental benefits of electric vehicles: A case study of Shanghai.

Journal of environmental management·2025
Same author

Comparative study of the aesthetic outcomes of two techniques for bilateral cleft lip repair.

The British journal of oral & maxillofacial surgery·2025
Same author

Wireless Flexible Actuator Photoelectric Synergistically Driven for Environment Adaptability Crawling Robots.

ACS applied materials & interfaces·2025
Same author

Novel technique and outcomes of umbilical reconstruction during cytoreductive surgery; a multi-centre study.

Techniques in coloproctology·2025
Same author

Canadian Surgery Forum: Abstracts of presentations to the Annual Meetings of the Canadian Association of Bariatric Physicians and Surgeons, Canadian Association of General Surgeons, Canadian Association of Thoracic Surgeons, Canadian Hepato-Pancreato-Biliary Association, Canadian Society of Surgical Oncology, Canadian Society of Colon and Rectal Surgeons, Vancouver, BC, Sept. 17-21, 2013.

Canadian journal of surgery. Journal canadien de chirurgie·2025

Surface chemistry minimally impacted blood cell activation and deposition on most biomaterials. However, specific materials like polyethylene-CF(4) showed higher reactivity, highlighting the need for tailored hemocompatibility testing for cardiovascular devices.

Area of Science:

  • Biomaterials Science
  • Hemocompatibility Testing
  • Surface Chemistry

Background:

  • Evaluating the hemocompatibility of cardiovascular devices is crucial for patient safety.
  • Standardized assays are needed to screen new blood-contacting biomaterials according to ISO-10993-4.
  • Surface chemistry can influence interactions between biomaterials and blood components.

Purpose of the Study:

  • To define assays for evaluating hemocompatibility of cardiovascular devices.
  • To clarify specific requirements of ISO-10993-4 for biomaterial screening.
  • To establish an appropriate screening program for novel blood-contacting biomaterials.

Main Methods:

  • Exposure of 12 unmodified and plasma-modified tubings to blood.
  • Assessment of platelet and leukocyte activation and cell deposition using scanning electron microscopy (SEM) and flow cytometry.

Related Experiment Videos

  • Characterization of materials using X-ray photoelectron spectroscopy (XPS) and contact angle measurements.
  • Evaluation of coagulation (PTT) and complement activation (SC5b-9, C3a).

    • Main Results:

    • Most materials showed minimal differences in platelet and leukocyte activation and cell deposition.
    • All tested materials activated platelets and leukocytes to detectable levels.
    • Polyethylene (PE) was the least reactive, while PE-CF(4) was the most reactive.
    • Specific assays like platelet microparticle formation, PTT, and complement activation distinguished material differences.

    Conclusions:

    • Surface chemistry has a limited, but material-specific, effect on hemocompatibility.
    • A combination of assays is effective in differentiating the hemocompatibility of blood-contacting biomaterials.
    • The study provides a basis for developing a robust screening program for cardiovascular device materials.