[Changes in some plasma parameters in the course of dextran 40]

Area of Science:

• Cardiovascular Physiology
• Pharmacology

Background:

• Dextran 40 is a plasma volume expander used in clinical settings.
• Understanding its hemodynamic effects is crucial for patient management.

Purpose of the Study:

• To investigate the impact of two different Dextran 40 infusion rates and volumes on key plasma parameters.
• To assess the expander effect, duration, and potential adverse reactions.

Main Methods:

• Fifty patients received Dextran 40 infusions at two different regimens: 500 ml at 40 drops/min and 250 ml at 20 drops/min.
• Plasma parameters including hematocrit (Hc), venous pressure (VP), creatinine clearance, potassium, pulmonary artery pressure (PA), and cardiac output (FC) were monitored.

Main Results:

• Higher Dextran 40 volume (500 ml) resulted in a more intense but less prolonged expander effect.
• The venous system was primarily affected, with increases in blood potassium, cardiac output (FC), and maximal pulmonary artery pressure (PA), alongside decreases in minimal PA and blood proteins.
• No significant changes in hematocrit (Hc) were observed for 24 hours (higher dose) and 96 hours (lower dose).

Conclusions:

• Dextran 40 administration causes significant hemodynamic changes, primarily in the venous circulation.
• The intensity and duration of effects are dose-dependent.
• No intolerance or significant adverse effects related to creatinine clearance or diuresis were noted.