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Evaluation of the tablet coating by the conventional spouted-bed process
G D Silva1, M C Publio, W P Oliveira
1Laboratory of Industrial Physics, Faculty of Pharmaceutical Sciences of Ribeirão Preto, University of São Paulo, Ribeirão Preto, SP, 14040-903.
Drug Development and Industrial Pharmacy
|April 9, 2001
Summary
This study analyzed tablet coating using the spouted-bed process, finding that coating suspension flow rate significantly impacts coating efficiency and adhesion. The weighing method is validated for analyzing tablet coating processes.
Area of Science:
- Pharmaceutical Technology
- Chemical Engineering
- Materials Science
Background:
- Spouted-bed coating is a common pharmaceutical process.
- Understanding process parameters is crucial for optimizing tablet coating.
Purpose of the Study:
- Analyze tablet coating using the conventional spouted-bed process.
- Evaluate equipment performance and product quality.
- Validate methods for describing coating kinetics.
Main Methods:
- Determined tablet mass increase rate (K1) and adhesion coefficient (eta).
- Investigated K1 and eta as functions of coating suspension flow rate (Ws), Reynolds number (Rep), atomizing gas flow rate (Wat), and cone base angle (gamma).
- Assessed coating uniformity using weighing, image analysis, and micrometer measurements; compared with a literature model.
Main Results:
- K1 and eta increased with coating suspension flow rate (Ws).
- The weighing method accurately reflects particle diameter increase over time.
- The growth model effectively describes coating kinetics.
- Coating deposition was not uniform across the tablet surface.
Conclusions:
- Coating suspension flow rate (Ws) is the most influential variable on K1 and eta.
- The weighing method is suitable for process analysis.
- The employed growth model is valid for describing coating kinetics.
- Non-uniform coating deposition is a key challenge.