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Updated: Aug 9, 2026

Cecal Ligation Puncture Procedure
Published on: May 7, 2011
Sepsis and cholestasis
1Medical Service, Ann Arbor Veterans Affairs Health System, Michigan, USA. rmoseley@umich.edu
Abstract:
Sepsis-associated cholestasis should always be considered as part of the differential diagnosis of jaundice in the hospitalized or critically ill patient. The development of a disproportionate elevation of serum bilirubin in comparison with serum alkaline phosphatase and serum aminotransferases should be considered an early warning sign of an underlying infection, even in the absence of fever, leukocytosis, or other signs or symptoms. Prompt recognition and appropriate medical and surgical intervention may reduce morbidity and mortality.
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