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Bilateral breast metastases from choroidal melanoma
H Demirci1, C L Shields, J A Shields
1Oncology Service, Wills Eye Hospital, Thomas Jefferson University, Philadelphia, Pennsylvania 19107, USA.
American Journal of Ophthalmology
|April 9, 2001
Summary
This case report details a rare instance of breast metastases originating from choroidal melanoma. Such metastases are uncommon, and breast nodules in these patients may be primary tumors or rare melanoma metastases.
Area of Science:
- Ophthalmology
- Oncology
- Pathology
Background:
- Choroidal melanoma is a rare intraocular malignancy.
- Metastasis from choroidal melanoma typically occurs in the liver, lungs, and bone.
- Breast metastasis from choroidal melanoma is exceptionally rare.
Observation:
- A 48-year-old woman with choroidal melanoma underwent Iodine-125 brachytherapy.
- She developed sequential, solitary bilateral breast metastases 37 and 54 months post-treatment.
- Both breast lesions were surgically removed, and systemic surveillance revealed no other metastatic disease.
Findings:
- This case highlights the possibility of breast tissue as a site for choroidal melanoma metastasis.
- The metastases were solitary and sequential, appearing in separate breasts over time.
- The patient remained free of other metastatic disease at 61 months post-treatment.
Implications:
- Clinicians should consider metastatic choroidal melanoma in the differential diagnosis of breast nodules in affected patients.
- Early detection and management of rare metastases are crucial for patient outcomes.
- Further research is needed to understand the patterns and risk factors for rare metastatic sites in uveal melanoma.