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Experimental oral candidiasis in animal models
Y H Samaranayake1, L P Samaranayake
1Oral Biosciences, Faculty of Dentistry, The University of Hong Kong, Hong Kong SAR, China.
Clinical Microbiology Reviews
|April 9, 2001
Summary
Animal models for oral candidiasis, including primates, rats, and mice, are crucial for studying host factors in infection. However, variations in study design and animal specifics complicate comparisons, highlighting the need for standardized protocols.
Area of Science:
- Microbiology
- Immunology
- Infectious Diseases
Background:
- Oral candidiasis results from host vulnerability and pathogen virulence.
- Animal models are essential for investigating host predisposing factors in oral candidiasis.
Purpose of the Study:
- To review animal experiments on host factors in oral candidiasis.
- To evaluate the suitability and limitations of different animal models for studying oral candidiasis.
Main Methods:
- Literature review of animal experiments on oral candidiasis.
- Analysis of primate, rat, and mouse models for oral candidiasis research.
Main Results:
- Primate models are suitable for denture stomatitis but are costly.
- Rat models are effective for chronic oral candidal infections due to availability and ease of use.
- Mouse models, with genetic variants, are useful for short-term immune response studies.
Conclusions:
- No single ideal, inexpensive animal model currently exists for oral candidiasis research.
- Standardization of experimental protocols is crucial for comparable and meaningful data across studies.
- Further development of representative animal models is needed to fully understand oral candidiasis in humans.