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Primary endometrial T-cell lymphoma. A case report.
C M Kirk1, R W Naumann, C J Hartmann
1Dept of Pathology, Carolinas Medical Center, 1000 Blythe Blvd, Charlotte, NC 28203, USA.
American Journal of Clinical Pathology
|April 11, 2001
Summary
Primary endometrial T-cell lymphoma is rare. This case in a US woman showed a favorable outcome with early-stage disease, suggesting localized peripheral T-cell lymphomas can be effectively treated.
Area of Science:
- Gynecologic Oncology
- Hematology
- Pathology
Background:
- Primary lymphomas of the female genital tract are uncommon, typically affecting the cervix.
- Most reported cases are B-cell lymphomas; T-cell lymphomas are exceptionally rare.
- Previous T-cell lymphoma reports include one endometrial case in a Japanese woman.
Observation:
- A case of diffuse large cell lymphoma of the endometrium is presented in a white woman from the United States.
- Immunophenotypic and molecular studies confirmed a peripheral T-cell lymphoma.
- Staging revealed the tumor was confined to the endometrium (Stage IE).
Findings:
- The patient underwent surgical treatment (hysterectomy, oophorectomy, lymph node dissection) followed by chemotherapy.
- The patient remained disease-free for 36 months post-treatment.
- This presentation suggests localized extranodal peripheral T-cell lymphoma can have a favorable prognosis.
Implications:
- Highlights the possibility of peripheral T-cell lymphomas presenting as localized extranodal disease.
- Supports aggressive multimodal treatment for early-stage endometrial T-cell lymphoma.
- Contributes to understanding the histogenesis and differential diagnosis of rare gynecologic lymphomas.