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Updated: Aug 4, 2026
08:12
Isolation of Human Neutrophils from Whole Blood and Buffy Coats
Published on: September 17, 2021
[Granulocytes transfusion for neutropenic patients]
J Fernández1, V Pressiani, J Solimano
1Unidades de Trasplante de Médula Osea, CEMIC, Buenos Aires, Argentina. pp22@arnet.com.ar
Medicina
|April 11, 2001
Summary
Granulocyte transfusions are gaining renewed interest for severe neutropenia due to improved collection methods. This review covers clinical data, donor selection, and adverse effects, aiming to re-establish their role in patient management.
Area of Science:
- Hematology
- Transfusion Medicine
Context:
- Severe and prolonged neutropenia poses significant risks to patients.
- Historical granulocyte transfusions had limited efficacy compared to current standards.
- Advances in mobilization and collection techniques have improved granulocyte product quality.
Purpose:
- To review the clinical experience and advancements in granulocyte transfusions over the past three decades.
- To evaluate the efficacy and safety of granulocyte transfusions for neutropenic patients.
- To provide updated guidelines and evidence for the use of granulocyte transfusions.
Summary:
- This review synthesizes literature data from the last 30 years on granulocyte transfusions.
- It details progress in donor selection, growth factor utilization, and mechanical apheresis for enhanced granulocyte collection.
- The review discusses adverse effects, current indications, and personal experiences, aiming to inform future clinical practice.
Impact:
- Improved granulocyte collection methods offer superior cellular products compared to historical data.
- This work aims to re-establish granulocyte transfusions as a viable supportive therapy for severely neutropenic patients.
- Evidence-based recommendations may prevent past disappointments and optimize patient outcomes.
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