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Ewing's sarcoma of bone: relation between clinical characteristics and staging
S Ferrari1, F Bertoni, M Mercuri
1Sezione di Chemioterapia, Istituto Ortopedico Rizzoli, I-40136 Bologna, Italy. stefano.ferrari@ior.it
Oncology Reports
|April 11, 2001
Summary
Clinical factors like tumor location, fever, and elevated LDH predict metastatic Ewing sarcoma. Identifying these risk factors can help determine prognosis and tailor treatment for patients with this aggressive bone cancer.
Area of Science:
- Oncology
- Pediatric Oncology
- Orthopedic Oncology
Background:
- Metastatic Ewing's sarcoma of bone carries a poor prognosis.
- Early identification of metastatic disease is crucial for treatment planning.
Purpose of the Study:
- To investigate the relationship between clinical characteristics and the presence of metastatic disease at diagnosis in Ewing's sarcoma of bone.
- To identify clinical risk factors associated with metastatic Ewing's sarcoma at presentation.
Main Methods:
- Retrospective analysis of data from 618 patients diagnosed between 1972 and 1997.
- Multivariate logistic regression analysis to identify significant risk factors for metastatic disease.
Main Results:
- Pelvic tumor location, high lactate dehydrogenase (LDH) levels, fever, symptom onset to diagnosis interval < 3 months, and age > 12 years were identified as risk factors.
- The rate of metastatic disease increased significantly with the number of risk factors present, from 4% with no factors to 44% with 3-4 factors.
- All patients with five risk factors presented with metastases.
Conclusions:
- The identified clinical parameters serve as markers for Ewing's sarcoma with aggressive metastatic behavior.
- These findings can aid in predicting the likelihood of metastasis at diagnosis.
- Risk stratification based on these factors may inform treatment strategies for Ewing's sarcoma.