Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Whats new in genodermatoses?

M W Fear1, S J Hatsell, I M Leigh

  • 1Centre for Cutaneous Research, St. Bartholomews', Royal London School of Medicine and Dentistry, Queen Mary and Westfield College, 2 Newark Street, Whitechapel, London E1 2AT, UK.

The Keio Journal of Medicine
|April 12, 2001
PubMed
Summary

Recent studies reveal that proteins regulating epidermal cell junctions are crucial for skin health, particularly in palmoplantar keratodermas. Mutations in these junction proteins cause various skin diseases.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Coherency image analysis to quantify collagen architecture: implications in scar assessment.

RSC advances·2022
Same author

Platelets after burn injury - hemostasis and beyond.

Platelets·2022
Same author

Early inflammation precedes cardiac fibrosis and heart failure in desmoglein 2 murine model of arrhythmogenic cardiomyopathy.

Cell and tissue research·2021
Same author

Pioneers in Dermatology and Venereology: an interview with Prof. Irene M. Leigh.

Journal of the European Academy of Dermatology and Venereology : JEADV·2020
Same author

Advanced cutaneous squamous cell carcinoma - a pressing case for treatment.

Journal of the European Academy of Dermatology and Venereology : JEADV·2019
Same author

A novel homozygous nonsense mutation in CAST associated with PLACK syndrome.

Cell and tissue research·2019

Area of Science:

  • Dermatology
  • Cell Biology
  • Genetics

Background:

  • Genodermatoses, specifically palmoplantar keratodermas, are linked to genetic factors.
  • Epidermal cell junctions play a vital role in maintaining skin structure and function.

Purpose of the Study:

  • To highlight the significance of proteins involved in epidermal cell junction formation and regulation.
  • To explore the connection between mutations in junction proteins and skin diseases.

Main Methods:

  • Genetic analysis of genodermatoses.
  • Review of literature on epidermal cell junctions and associated proteins.

Main Results:

  • Identification of key proteins regulating epidermal cell junctions.

Related Experiment Videos

  • Demonstration of the importance of gap junctions, desmosomes, and adherens junctions in skin.
  • Association of mutations in desmoplakin and connexins with epidermal diseases.

    • Conclusions:

    • Proteins regulating epidermal cell junctions are critical for normal skin.
    • Defects in these junctions contribute to the pathogenesis of genodermatoses like palmoplantar keratodermas.