Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Microscopic polyangiitis (microscopic polyarteritis).

J C Jennette1, D B Thomas, R J Falk

  • 1Department of Pathology and Laboratory Medicine, University of North Carolina, Chapel Hill 27599-7525, USA.

Seminars in Diagnostic Pathology
|April 12, 2001
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Injection of ANCA-No Neutrophils, No Glomerular Damage: The Role of Neutrophils in the Induction of Glomerulonephritis by Anti-Myeloperoxidase Antibodies. Am J Pathol 167: 39-45, 2005.

Journal of the American Society of Nephrology : JASN·2023
Same author

Higher Beetle Diversity in Native Vegetation Than in Stands of the Invasive Arundo, Arundo donax L., along the Rio Grande Basin in Texas, USA.

Journal of insect science (Online)·2018
Same author

Resolution of inter and intra-species relationships of the West Indian fruit fly Anastrepha obliqua.

Molecular phylogenetics and evolution·2016
Same author

Glucagon increases energy expenditure independently of brown adipose tissue activation in humans.

Diabetes, obesity & metabolism·2015
Same author

Reply to Comment on: 'Possible pro-carcinogenic association of endotoxin on lung cancer among Shanghai women textile workers'.

British journal of cancer·2014
Same author

Possible pro-carcinogenic association of endotoxin on lung cancer among Shanghai women textile workers.

British journal of cancer·2014
Same journal

Update on the molecular pathology of the distinctive giant cell, fibro-osseous and bone forming lesions of the jaws.

Seminars in diagnostic pathology·2026
Same journal

Update on the molecular pathology and classification of odontogenic cysts and tumours.

Seminars in diagnostic pathology·2026
Same journal

MDM2 gene amplification in surgical pathology: biology, diagnostic utility, and clinical relevance in the modern era.

Seminars in diagnostic pathology·2026
Same journal

When three negatives equal a positive: Molecular updates of triple-negative breast carcinomas with favorable prognoses.

Seminars in diagnostic pathology·2026
Same journal

Old school, new insight: Revisiting histomorphology in the modern era of prostate cancer risk stratification.

Seminars in diagnostic pathology·2026
Same journal

Recent advances in genetic predisposition to primary testicular tumors.

Seminars in diagnostic pathology·2026
See all related articles

Microscopic polyangiitis is a necrotizing small vessel vasculitis. It is distinguished from other vasculitides by pauci-immune glomerulonephritis and pulmonary capillaritis, often without immune deposits.

Area of Science:

  • Rheumatology
  • Nephrology
  • Pulmonology

Background:

  • Microscopic polyangiitis (MPA) is a necrotizing small vessel vasculitis.
  • MPA primarily affects venules, capillaries, arterioles, and small arteries.
  • It is differentiated from immune complex vasculitis by the absence of significant immunoglobulin deposition.

Purpose of the Study:

  • To clarify the distinct pathological and clinical features of microscopic polyangiitis.
  • To differentiate MPA from other small and medium-sized vessel vasculitides.
  • To highlight MPA's common renal and pulmonary manifestations.

Main Methods:

  • Pathological examination of vessel walls, focusing on inflammation and immune deposits.
  • Clinical assessment of patient symptoms, including renal and pulmonary involvement.

Related Experiment Videos

  • Serological testing for antineutrophil cytoplasmic autoantibodies (ANCAs).

    • Main Results:

    • MPA is characterized by pauci-immune necrotizing and crescentic glomerulonephritis.
    • Hemorrhagic pulmonary capillaritis is a frequent finding in MPA.
    • MPA shares pathological features with Wegener's granulomatosis and Churg-Strauss syndrome but lacks granulomatous inflammation or eosinophilia, respectively.
    • Circulating ANCAs are associated with MPA, Wegener's granulomatosis, and Churg-Strauss syndrome.

    Conclusions:

    • Microscopic polyangiitis is a distinct vasculitic entity characterized by small vessel necrotizing inflammation.
    • Pauci-immune glomerulonephritis and pulmonary capillaritis are hallmarks of MPA.
    • Distinguishing MPA from other ANCA-associated vasculitides relies on the absence of granulomatous inflammation and eosinophilia.