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Acute creatine loading enhances human growth hormone secretion.

J M Schedel1, H Tanaka, A Kiyonaga

  • 1Laboratory of Exercise Physiology and Biomechanics, Graduate School of Physical Education, Chukyo University, Toyota, Japan. Jean-Marc.Schedel@iphysiol.unil.ch

The Journal of Sports Medicine and Physical Fitness
|April 12, 2001
PubMed
Summary

Acute creatine (Cr) ingestion significantly stimulates human growth hormone (GH) secretion in healthy males at rest. This effect, though variable, highlights creatine

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Area of Science:

  • Exercise Physiology
  • Endocrinology
  • Nutritional Science

Background:

  • Creatine supplementation is widely used to enhance athletic performance.
  • The acute effects of creatine on endocrine responses, particularly human growth hormone (GH), remain under investigation.

Purpose of the Study:

  • To investigate the impact of acute creatine ingestion on the secretion of human growth hormone (GH) in healthy males.
  • To compare GH levels following creatine supplementation versus a control condition.

Main Methods:

  • A comparative cross-sectional study involving 6 healthy male subjects.
  • Subjects ingested a single 20g dose of creatine (Cr-test) or a placebo (c-test) under resting conditions.
  • Blood serum concentrations of creatine, creatinine, and GH were measured for 6 hours post-ingestion.

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Main Results:

  • A significant stimulation of GH secretion (p<0.05) was observed during the Cr-test compared to the c-test.
  • A substantial interindividual variability in GH response was noted, with an average increase of 83% (SD 45%).
  • Peak GH concentrations typically occurred between 2 and 6 hours after acute creatine ingestion.

Conclusions:

  • High-dose acute creatine ingestion enhances GH secretion in resting individuals.
  • This creatine-induced GH response mimics the effects of strenuous exercise.
  • The indirect anabolic properties of creatine, including acute body weight gain and strength increase, should be considered in light of its effect on GH secretion.