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Related Experiment Videos

Allergens from fish and egg.

L K Poulsen1, T K Hansen, A Nørgaard

  • 1Allergy Unit, National University Hospital, Copenhagen, Denmark. lkpallgy@inet.uni2.dk

Allergy
|April 12, 2001
PubMed
Summary
This summary is machine-generated.

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Common food allergens like fish and egg cause frequent allergic reactions. Research highlights key allergens such as Gad c1 in fish and egg proteins (Gal d1-d4), noting cross-reactivity in fish allergies.

Area of Science:

  • Immunology
  • Food Allergy Research
  • Molecular Allergology

Background:

  • Fish and egg allergens are frequent causes of food allergic reactions.
  • Egg allergens include ovomucoid, ovalbumin, ovotransferrin, lysozyme (Gal d1-d4) in egg white, and alpha-livitin in egg yolk.
  • The primary fish allergen is Gad c1 homologues from cod, a calcium-binding protein.

Purpose of the Study:

  • To review the literature on fish and egg allergens.
  • To emphasize the scarcity of cloned allergens in these systems.
  • To highlight the clinical relevance of cross-reactivity in fish allergies.

Main Methods:

  • Literature review of studies on fish and egg allergens.
  • Analysis of allergen nomenclature and identified proteins.

Related Experiment Videos

  • Examination of cross-reactivity data, including double-blind, placebo-controlled food challenges.
  • Main Results:

    • Identified major egg allergens: Gal d1-d4 (white) and alpha-livitin (yolk).
    • Identified Gad c1 homologues (parvalbumins) as the main fish allergen family.
    • Demonstrated clinical relevance of cross-reactivity within fish species (e.g., cod, herring, plaice, mackerel).

    Conclusions:

    • Fish and egg allergens are significant contributors to food allergies.
    • Parvalbumins in fish exhibit clinically relevant cross-reactivity.
    • There is a need for more research and cloned allergens for both fish and egg systems.