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[Multiple sclerosis: clinical and laboratorial correlation].

M Puccioni-Sohler1, F P Lavrado, R R Bastos

  • 1Projeto Atlântico-Sul, Laboratório Especializado de LCR (Neurolife), Rio de Janeiro, Brasil. sohler@netyet.com.br

Arquivos De Neuro-Psiquiatria
|April 12, 2001
PubMed
Summary
This summary is machine-generated.

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Corticosteroid treatment for multiple sclerosis (MS) reduces intrathecal IgG synthesis but does not affect oligoclonal IgG bands in cerebrospinal fluid (CSF). This highlights immunological differences in MS disease courses.

Area of Science:

  • Neuroimmunology
  • Clinical Neurology

Context:

  • Multiple Sclerosis (MS) is a chronic inflammatory demyelinating disease of the central nervous system.
  • Cerebrospinal fluid (CSF) analysis, including IgG index and oligoclonal bands, aids in MS diagnosis and monitoring.
  • Understanding the immunological differences between relapsing-remitting MS (RRMS) and chronic progressive MS (CPMS) is crucial for treatment strategies.

Purpose:

  • To compare clinical and demographic characteristics of Brazilian MS patients with their CSF findings.
  • To investigate the impact of corticosteroid treatment on intrathecal IgG synthesis and oligoclonal band presence in MS patients.

Summary:

  • This study analyzed 86 Brazilian patients with clinically definite MS, correlating clinical data with CSF findings.
  • Elevated IgG index was more frequent in CPMS (76%) compared to bout (46%) and remission (49%) phases of RRMS (p < 0.005).

Related Experiment Videos

  • Corticosteroid use was associated with a lower incidence of increased IgG index (36%) versus non-users (64%), while oligoclonal IgG bands were detected in 77% of users and 88% of non-users.

    • Impact:

    • The findings quantitatively demonstrate immunological differences between RRMS and CPMS.
    • Corticosteroid therapy quantitatively reduces intrathecal IgG synthesis in MS patients.
    • Corticosteroid treatment does not appear to affect the presence of oligoclonal IgG bands in CSF.