Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Should weaker study designs ever be preferred over randomised controlled trials.

D Chaloner1, J Cave

  • 1Walsall Community Health Trust.

Journal of Tissue Viability
|April 13, 2001
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Simulated endorectal Soave pull-through for Hirschsprung's disease using a piglet model.

Annals of the Royal College of Surgeons of England·2022
Same author

Exercise prehabilitation may lead to augmented tumor regression following neoadjuvant chemoradiotherapy in locally advanced rectal cancer.

Acta oncologica (Stockholm, Sweden)·2019
Same author

A systematic review of the safety and efficacy of aerobic exercise during cytotoxic chemotherapy treatment.

Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer·2018
Same author

Proactive multi-modality treatment of Pancreatic Neuroendocrine Tumours (PNETs): Potential survival benefits.

Pancreatology : official journal of the International Association of Pancreatology (IAP) ... [et al.]·2018
Same author

Clinical trials: comparing dressings.

Nursing standard (Royal College of Nursing (Great Britain) : 1987)·2016
Same author

Neuroaxonal dystrophy in Merino-Border Leicester × Polled Dorset lambs.

Australian veterinary journal·2014
Same journal

Corrigendum to "A comprehensive study on mechanisms of action of fibroin, aloe vera, and ginger extracts through histochemical, inflammation biomarkers, and matrix metalloproteinases analysis against diabetic wounds" [J Tissue Viability 33 (2024) 949-959].

Journal of tissue viability·2026
Same journal

Wearable-device geometry and tissue mechanical variability determine sacral soft-tissue loading and pressure injury risk.

Journal of tissue viability·2026
Same journal

Corrigendum to "Evaluation methods of pressure injury stages: A systematic review and meta-analysis" [J Tissue Viability 34 3100894 (2025)].

Journal of tissue viability·2026
Same journal

The effects of hypoxia environment at high-altitudes on inflammation and angiogenesis in wound healing process:A meta-analysis and review.

Journal of tissue viability·2026
Same journal

Sacral positioning and interface pressure in the beach-chair position during shoulder surgery: a retrospective, observational study.

Journal of tissue viability·2026
Same journal

Clinical decision support tools in wound management: A scoping review of existing and emerging tools.

Journal of tissue viability·2026
See all related articles

A randomized controlled trial found no significant difference in sore incidence between two alternating pressure air mattresses. The study was under-powered, suggesting other designs might better capture user experience for purchasing decisions.

Area of Science:

  • Medical Devices
  • Clinical Trials
  • Pressure Ulcer Prevention

Background:

  • Randomized controlled trials (RCTs) are considered the gold standard for evaluating medical device efficacy.
  • Pressure-redistributing beds and mattresses are crucial for preventing pressure ulcers.
  • Comparing different types of alternating pressure air mattresses requires robust study designs.

Purpose of the Study:

  • To compare the effectiveness of two alternating pressure air mattresses in preventing pressure sores.
  • To evaluate the suitability of RCTs for assessing mattress efficacy in real-world purchasing contexts.

Main Methods:

  • A randomized controlled trial (RCT) design was employed.
  • Two distinct alternating pressure air mattresses were compared.

Related Experiment Videos

  • The primary outcome measured was the incidence of pressure sores.

    • Main Results:

    • No statistically significant difference was observed in the incidence of pressure sores between the two tested mattresses.
    • The study was found to be under-powered, potentially masking real differences in efficacy.
    • The limitations of RCTs in capturing user experience for procurement were highlighted.

    Conclusions:

    • While this RCT found no significant difference, its under-powered nature limits definitive conclusions on mattress efficacy.
    • Alternative study designs, incorporating user experience, may offer more practical insights for mattress purchasers.
    • Further research with adequate power is needed to definitively compare alternating pressure air mattresses.