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Updated: Jul 11, 2026

Intralymphatic Immunotherapy and Vaccination in Mice
Published on: February 2, 2014
Challenges and controversies in immunization safety
R T Chen1, F DeStefano, R Pless
1National Immunization Program, Centers for Disease Control and Prevention, Atlanta, Georgia, USA. rtc1@cdc.gov
Abstract:
No vaccine is perfectly safe or effective. As diseases such as diphtheria and polio fade, vaccine safety concerns, especially alleged links between vaccinations and several chronic illnesses, have become increasingly prominent in the media and to the public. This article reviews the current scientific evidence on several recent vaccine safety controversies. It also provides information on how various safety research is conducted, some of the concurrent challenges, and finally, some guidance on communicating with patients on vaccine risks.
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