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Related Experiment Videos

Axillary pheromones modulate pulsatile LH secretion in humans.

K Shinohara1, M Morofushi, T Funabashi

  • 1Department of Physiology, Yokohama City University School of Medicine, Yokohama, Japan.

Neuroreport
|April 17, 2001
PubMed
Summary

Human pheromones from axillary compounds influence reproductive timing. Follicular phase compounds increase luteinizing hormone (LH) pulse frequency, while ovulatory phase compounds decrease it, suggesting a role in ovulation timing.

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Area of Science:

  • Reproductive endocrinology
  • Human pheromone research
  • Neuroendocrinology

Background:

  • Pulsatile secretion of luteinizing hormone (LH) is critical for reproductive function.
  • The potential role of human pheromones in modulating reproductive processes remains an area of active investigation.
  • Axillary compounds contain volatile chemicals that may act as signaling molecules.

Purpose of the Study:

  • To investigate the effect of axillary compounds collected during different phases of the menstrual cycle on pulsatile LH secretion in humans.
  • To determine if these compounds act as pheromones influencing reproductive endocrine events.

Main Methods:

  • Axillary compounds were collected from women during the follicular phase (FP) and ovulatory phase (OP).
  • Compounds were treated with isopropyl alcohol (IPA).

Related Experiment Videos

  • Recipient women were exposed to FP compounds, OP compounds, or IPA for 4 hours after an initial 4-hour control period, with LH pulse frequency monitored.

    • Main Results:

    • Exposure to follicular phase (FP) axillary compounds significantly increased the frequency of LH pulses.
    • Exposure to ovulatory phase (OP) axillary compounds significantly decreased the frequency of LH pulses.
    • Isopropyl alcohol (IPA) exposure did not alter LH pulse frequency, indicating the effects were due to the axillary compounds themselves.

    Conclusions:

    • Human axillary compounds, potentially acting as pheromones, can modulate pulsatile LH secretion.
    • These findings suggest a mechanism by which pheromones may influence the timing of ovulation in humans.
    • The differential effects of FP and OP compounds highlight the dynamic signaling capacity of human axillary secretions in reproductive endocrinology.