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Carbon disulfide vasculopathy: a small vessel disease
1Department of Neurology, Chang Gung Memorial Hospital and University, Taipei, Taiwan. cch0537@adm.cgmh.com.tw
Cerebrovascular Diseases (Basel, Switzerland)
|April 18, 2001
Summary
Long-term carbon disulfide (CS2) exposure in viscose rayon workers can cause stroke-like symptoms and polyneuropathy. This occupational hazard may lead to progressive brain lesions, even after exposure cessation, highlighting CS2 as a potential stroke risk factor.
Area of Science:
- Neuroscience
- Occupational Health
- Toxicology
Background:
- Investigating the neurological effects of chronic carbon disulfide (CS2) exposure in industrial settings.
- Understanding the link between occupational chemical exposure and cerebrovascular events.
Observation:
- Four male viscose rayon plant workers developed acute stroke-like symptoms and polyneuropathy after prolonged CS2 exposure.
- Clinical presentation included hemiparesis, with neuroimaging revealing lesions in the basal ganglia, corona radiata, thalamus, and brainstem.
- Cerebral angiography excluded significant large vessel stenosis, suggesting small vessel disease.
Findings:
- CS2 intoxication led to encephalopathy characterized by stroke-like episodes and progressive cerebral lesions.
- Lesions predominantly affected small cerebral vessels in areas like the basal ganglia and brainstem.
- Neurological deficits persisted and new lesions emerged even after removal from CS2 exposure.
Implications:
- Carbon disulfide (CS2) exposure is identified as a significant risk factor for stroke.
- This study underscores the need for stringent occupational health measures to prevent CS2-related neurological damage.
- Early diagnosis and intervention are crucial for managing CS2-induced encephalopathy and preventing further cerebrovascular complications.
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