Related Experiment Video
Updated: Jul 15, 2026
09:58
A Reversible, Non-invasive Method for Airway Resistance Measurements and Bronchoalveolar Lavage Fluid Sampling in Mice
Published on: April 13, 2010
Nerve growth factor induces airway hyperresponsiveness in mice
A Braun1, D Quarcoo, O Schulte-Herbrüggen
1Abteilung für Klinische Chemie und Molekulare Diagnostik, Klinikum der Philipps-Universität Marburg, Germany. braunar@post.med.uni-marburg.de
International Archives of Allergy and Immunology
|April 18, 2001
Summary
Nerve growth factor (NGF) induces airway hyperresponsiveness in mice, even without inflammation. This suggests NGF plays a direct role in the development of this respiratory condition.
Area of Science:
- Pulmonary immunology
- Neuroscience
- Respiratory physiology
Background:
- Nerve growth factor (NGF) production is upregulated during allergic inflammation.
- The precise function of NGF in lung pathophysiology, particularly airway hyperresponsiveness, remains unclear.
- The interplay between immune responses and neuronal control of airway smooth muscle is not fully defined.
Purpose of the Study:
- To investigate the role of NGF in the induction of airway hyperresponsiveness.
- To determine if NGF can cause airway hyperresponsiveness independently of inflammation.
Main Methods:
- Nerve growth factor (NGF) was administered to mouse airways via nasal instillation.
- Genetically engineered mice overexpressing NGF in Clara cells were utilized.
- Airway reactivity was assessed using electrical field stimulation.
Main Results:
- Direct NGF treatment in mice led to significant airway hyperresponsiveness, comparable to allergen-sensitized models.
- Mice genetically engineered to overexpress NGF exhibited heightened airway reactivity compared to wild-type controls.
- These findings indicate NGF can induce airway hyperresponsiveness without concurrent airway inflammation.
Conclusions:
- Nerve growth factor (NGF) is a key factor in the development of airway hyperresponsiveness.
- NGF can independently induce airway hyperresponsiveness, highlighting its direct role in respiratory pathophysiology.
- These results provide crucial insights into the neuro-immune mechanisms underlying airway hyperreactivity.
Related Concept Videos
01:20Asthma: Pathogenesis and Management
Asthma is a chronic pulmonary condition involving inflammation of the airways, hyper-reactivity, and reversible obstruction of the airways. This condition can significantly impact a person's quality of life, making breathing difficult and leading to distressing symptoms.
Asthma is classified as allergic and non-allergic. Allergens such as dust mites, pollen, and pet dander trigger allergic asthma, while factors like cold air, intense emotions, or exercise can induce non-allergic asthma.
Asthma is classified as allergic and non-allergic. Allergens such as dust mites, pollen, and pet dander trigger allergic asthma, while factors like cold air, intense emotions, or exercise can induce non-allergic asthma.
01:28Asthma I: Introduction
Asthma is a chronic inflammatory disorder of the airways characterized by variable airflow obstruction and heightened bronchial responsiveness to a wide range of triggers. The underlying inflammation leads to airway swelling, mucus hypersecretion, and smooth muscle constriction, all of which narrow the airway lumen and impede airflow. Clinically, asthma presents with recurrent episodes of wheezing, shortness of breath, chest tightness, and coughing, symptoms that typically vary in intensity and...