Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Reversible brain dysfunction in MELAS: MEG, and (1)H MRS analysis.

K Kamada1, F Takeuchi, K Houkin

  • 1Department of Neurosurgery, School of Medicine, Hokkaido University, Kita-ku, Kita-15, Nishi-7, Sapporo, 060-8638, Japan. kamady1@qc4.so-net.ne.jp

Journal of Neurology, Neurosurgery, and Psychiatry
|April 20, 2001
PubMed
Summary

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Lean non-alcoholic fatty liver disease (lean NAFLD): characteristics, metabolic outcomes and risk factors from a 7-year prospective, community cohort study from Sri Lanka.

Hepatology international·2018
Same author

Particle size specific distribution of perfluoro alkyl substances in atmospheric particulate matter in Asian cities.

Environmental science. Processes & impacts·2017
Same author

Serum anti-citrullinated protein antibodies of a mother with rheumatoid arthritis pass through the placenta but do not cause arthritis in her neonate.

Scandinavian journal of rheumatology·2016
Same author

Online control of a humanoid robot through hand movement imagination using CSP and ECoG based features.

Annual International Conference of the IEEE Engineering in Medicine and Biology Society. IEEE Engineering in Medicine and Biology Society. Annual International Conference·2016
Same author

Distinction of individual finger responses in somatosensory cortex using ECoG high-gamma activation mapping.

Annual International Conference of the IEEE Engineering in Medicine and Biology Society. IEEE Engineering in Medicine and Biology Society. Annual International Conference·2016
Same author

Genetic variants of Kudoa septempunctata (Myxozoa: Multivalvulida), a flounder parasite causing foodborne disease.

Journal of fish diseases·2015

This study tracked a patient with MELAS, a mitochondrial disease. Follow-up imaging revealed recovery of brain function and metabolism in stroke-like lesions, showing potential for neurological healing.

Area of Science:

  • Neuroscience
  • Biochemistry
  • Medical Imaging

Background:

  • Mitochondrial encephalopathy with lactic acidosis and stroke-like syndrome (MELAS) can cause significant neurological deficits.
  • Assessing the metabolic and functional recovery of MELAS-related brain lesions is crucial for understanding disease progression and treatment efficacy.

Observation:

  • Initial proton magnetic resonance spectroscopy ((1)H MRS) revealed no N-acetyl aspartate (NAA) and high lactate (Lac) in a MELAS stroke-like lesion, with auditory evoked magnetic fields (AEFs) showing no neural activity.
  • Follow-up investigations demonstrated the reappearance of NAA, a significant reduction in Lac, and a marked increase in AEFs within the lesion.

Findings:

  • Metabolic changes (NAA, Lac) and functional recovery (AEFs) in (1)H MRS and AEFs correlated well with the patient's neurological improvement.

Related Experiment Videos

  • The study highlights the capacity for functional recovery in MELAS stroke-like lesions despite initial severe damage from mitochondrial dysfunction.

    • Implications:

    • This case suggests that MELAS lesions may retain a potential for recovery, indicated by metabolic and functional improvements.
    • The combined use of (1)H MRS and AEFs provides valuable insights into the dynamic changes and recovery processes in MELAS brain lesions.
    • Further research into therapeutic strategies targeting mitochondrial dysfunction could enhance neurological recovery in MELAS patients.