Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Axonal polyneuropathy in obstructive sleep apnoea.

P Lüdemann1, R Dziewas, P Sörös

  • 1Department of Neurology, University of Münster, Albert-Schweitzer-Strasse 33, D-48129 Münster, Germany.

Journal of Neurology, Neurosurgery, and Psychiatry
|April 20, 2001
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

[Curriculum "Tracheostomy management in dysphagia therapy"].

HNO·2024
Same author

[Curriculum "Tracheostomy management in dysphagia therapy"].

Der Nervenarzt·2024
Same author

The German trial on Aciclovir and Corticosteroids in Herpes-simplex-virus-Encephalitis (GACHE): a multicenter, randomized, double-blind, placebo-controlled trial.

Neurological research and practice·2020
Same author

Dysphagia in COVID-19 -multilevel damage to the swallowing network?

European journal of neurology·2020
Same author

[Swallowing in the elderly : Physiological changes, dysphagia, diagnostics and treatment].

Zeitschrift fur Gerontologie und Geriatrie·2019
Same author

[Impact of anamnestic information and neurological deficits on the detection rate of secondary headaches].

Der Radiologe·2018

Obstructive sleep apnea (OSA) is linked to peripheral nerve damage. Patients with OSA show higher rates of polyneuropathy, with nerve damage severity correlating to nighttime oxygen levels.

Area of Science:

  • Neurology
  • Pulmonology
  • Sleep Medicine

Background:

  • Chronic hypoxemia in COPD is a known polyneuropathy risk factor.
  • The effect of intermittent hypoxemia on peripheral nerves remains unclear.
  • Obstructive sleep apnea (OSA) involves recurrent intermittent hypoxemia.

Purpose of the Study:

  • To investigate the prevalence of polyneuropathy in patients with OSA.
  • To determine if intermittent hypoxemia in OSA is an independent risk factor for peripheral nerve damage.

Main Methods:

  • A case-control study comparing 24 OSA patients with 21 matched controls.
  • Clinical assessment for polyneuropathy signs.
  • Electrophysiological testing, including sural sensory nerve action potential amplitude measurement.

Related Experiment Videos

  • Correlation analysis between polyneuropathy severity and nocturnal oxygen saturation levels.

    • Main Results:

    • A significantly higher prevalence of polyneuropathy was observed in OSA patients (71%) compared to controls (33%).
    • OSA patients exhibited reduced sural sensory nerve action potential amplitude, indicating axonal nerve damage.
    • The severity of axonal damage correlated with the percentage of time with oxygen saturation below 90% during the night.
    • These findings were independent of other known polyneuropathy risk factors.

    Conclusions:

    • Recurrent intermittent hypoxemia in OSA is a significant independent risk factor for axonal damage in peripheral nerves.
    • OSA is associated with a higher prevalence of polyneuropathy.
    • Nocturnal oxygen desaturation severity is linked to the extent of peripheral nerve damage in OSA patients.