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Scanning Electron Microscopy of Macerated Tissue to Visualize the Extracellular Matrix
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Scanning Electron Microscopy of Macerated Tissue to Visualize the Extracellular Matrix

Published on: June 14, 2016

Arterial fibrodysplasia. Histopathologic character and current etiologic concepts

J C Stanley, B L Gewertz, E L Bove

    Archives of Surgery (Chicago, Ill. : 1960)
    |May 1, 1975
    PubMed

    Insights

    Arterial fibrodysplasia, a vascular disease, affects numerous arteries, particularly renal arteries. This study identifies a new form of perimedial dysplasia and discusses potential causes like hormonal influences.

    Area of Science:

    • Vascular Medicine
    • Pathology
    • Genetics

    Background:

    • Arterial fibrodysplasia (AFD) is a non-atherosclerotic vascular disease.
    • It affects various arteries, with renal artery involvement being common.
    • Existing classifications include intimal fibroplasia and medial hyperplasia, with medical fibroplasia representing a disease continuum.

    Purpose of the Study:

    • To characterize the spectrum of arterial fibrodysplasia.
    • To identify and describe a previously unrecognized form of perimedial dysplasia.
    • To explore potential contributing factors to AFD development.

    Main Methods:

    • Retrospective analysis of 196 patients with arterial fibrodysplasia.
    • Detailed pathological examination of 316 affected vessels.
    • Histological assessment to identify distinct pathological entities.

    Main Results:

    • Arterial fibrodysplasia affected 196 patients (172 females, 24 males) with 316 diseased vessels.
    • Renal artery lesions were most frequent (152 adults, 25 pediatric).
    • A novel form of perimedial dysplasia, marked by peripheral medial elastic tissue accumulation, was identified.

    Conclusions:

    • Medical fibroplasia encompasses a range of pathological processes.
    • A distinct entity of perimedial dysplasia is recognized.
    • Hormonal influences, mechanical stresses, and vasa vasorum patterns may predispose individuals to arterial fibrodysplasia.

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