[The effect of duodenitis on the healing of chronic duodenal ulcers]

Dependence of healing of a chronic ulcer of the duodenum on structural changes of its mucosa was studied. A total of 95 patients with ulcerated lesions localized in the duodenal bulb at the stage of exacerbation were examined. Morphological changes were determined on the basis of the data of duodenoscopy and those of a histological investigation of the material obtained by the method of spot biopsy. The majority of patients examined showed the presence of duodenitis of a various degree of manifestation and mostly in the duodenal bulb in the distance from the ulcer. A clear-cut dependence of healing of ulcer on the presence and degree of gravity of changes in the duodenum was noted: in patients with unhealed ulcer duodenitis was more pronounced and persisted during the whole period of hospitalization of the patients despite the administered course of anti-ulcerous therapy.