[Effect of experimental inflammation of the appendix on immunogenesis]

Effects of an operation trauma and inflammation of the appendix caused by ligation of appendicular vessels on immunogenesis were studied in experiment on rabbits. A number of antibody-containing cells of plasmatic series in the blood serum and their percentage interrelation in the appendices were determined. A stimulating effect of laparotomy on the quantitative content of antibodies in the blood was established. Accelerated differentiation and restitution of the percentage interrelationship of antibody-containing cells in the appendix were noted at earlier periods as compared with controls in which similar phenomena were observed at later terms. The development of inflammation in the appendix in the majority of animals revealed itself in an increase of the antibody content in the blood at earlier periods and a decrease thereof at later periods. In the appendix the accelerated differentiation at earlier periods wes not completed subsequently by restitution of the percentage interrelationship of antibody-containing cellular forms.