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An elevation in the concentration of HLA class I molecules in human blood due to ageing
C Le Morvan1, M Cogné, M Drouet
1Laboratoire d'Immunologie et Immunogénétique UMR 6101, Faculté de Médecine, 2, rue du Docteur Marcland, 87025 Limoges, France.
Mechanisms of Ageing and Development
|April 20, 2001
Abstract:
The quantification of plasmatic HLA class-I molecules (sHLA-I) was realized by a sandwich ELISA using a monomorphic mAb (W6/32). sHLA-I concentration is significantly increased in the elderly group (>50 years, 0.429+/-0.301 microg ml(-1)) as compared to the young group (<50 years, 0.126+/-0.085 microg ml(-1)). The variation of sHLA-I content could contribute to the unresponsiveness of ageing immune system.