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Related Experiment Videos

Androgens and aging.

J E Morley1

  • 1Division of Geriatric Medicine, Room M238, Saint Louis University Medical School, 1402 South Grand Blvd, St. Louis, MO 63104-1028, USA. morley@sluvca.slu.edu

Maturitas
|April 20, 2001
PubMed
Summary
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Testosterone replacement therapy may benefit aging males with androgen deficiency (ADAM) cautiously. Oral testosterone undecanoate offers the best safety data, while more research is needed for women and other androgens like DHEA.

Area of Science:

  • Endocrinology
  • Geriatrics
  • Pharmacology

Background:

  • Aging males may experience symptoms of androgen deficiency (ADAM).
  • Testosterone replacement therapy (TRT) is a potential treatment option.
  • Limited data exists for TRT in postmenopausal women and other androgens.

Purpose of the Study:

  • To review the current evidence for testosterone replacement therapy in aging males.
  • To assess the safety and efficacy of different TRT formulations.
  • To explore the potential role of androgens in women and other steroid compounds.

Main Methods:

  • Literature review of studies on testosterone replacement therapy.
  • Analysis of safety data for oral testosterone undecanoate.
  • Evaluation of evidence for testosterone use in postmenopausal women and other androgens.

Related Experiment Videos

Main Results:

  • TRT may be appropriate for ADAM with caution.
  • Oral testosterone undecanoate has the best available safety data.
  • Insufficient data exists for testosterone use in postmenopausal women and for DHEA, DHEA-S, or pregnenolone.

Conclusions:

  • Cautious use of TRT for ADAM is supported.
  • Further research is essential for androgens in women and other compounds.
  • The field of androgens is rapidly evolving.