P-glycoprotein expression in squamous cell carcinoma of the oral and maxillofacial region
Related Experiment Video
Updated: Aug 4, 2026

RNAscope for In situ Detection of Transcriptionally Active Human Papillomavirus in Head and Neck Squamous Cell Carcinoma
Published on: March 11, 2014
1Department of Stomatology, First Affiliated Hospital, Zhejiang Medical University, No. 261 Qingchun Road, Hangzhou, 310003, P. R. China.
Objective:
To investigate the mechanism of drug resistance in oral and maxillofacial carcinoma to chemotherapy.
Materials And Methods:
Forty cases of squamous carcinoma in the oral and maxillofacial region were examined for the multidrug resistance gene product P-glycoprotein using a monoclonal antibody, MRK16.
Result:
P-glycoprotein was detected in 62.5% of all samples. P-glycoprotein expression was related to the chemotherapy and the differentiation of carcinoma. P-glycoprotein expression was higher in the post-chemotherapy group than in the non-chemotherapy group (P < 0.05). Well-differentiated tumors expressed P-glycoprotein more frequently (P < 0.05). P-glycoprotein expression was compared with clinical response to chemotherapy. The accuracy rate of prediction was 75%.
Conclusion:
P-glycoprotein plays an important role in mechanism of drug resistance of squamous cell carcinoma in the oral and maxillofacial region.
Related Concept Videos
Protein Glycosylation
Glycosylation occurs in...
Proteoglycans
Matrix Proteoglycans and Glycoproteins
Glycocalyx and its Functions
Components of...

