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Biphasic-flow induced ventilation allows simultaneous ventilation in several animals, using a single multiple output
E L'Her1, G Boulesteix, M Moriconi
1Medical Intensive Care Unit, Cavale Blanche University Hospital, Brest, France.
Summary
Biphasic-flow induced ventilation (BiFIV) efficiently ventilates multiple animals simultaneously using one device. This novel approach shows comparable oxygenation to conventional methods in a normal lung model.
Area of Science:
- Veterinary Medicine
- Respiratory Physiology
- Mechanical Ventilation
Background:
- Biphasic-flow induced ventilation (BiFIV) is a novel tracheal gas insufflation mode.
- Previous studies suggest BiFIV's efficacy in experimental settings.
- The potential for simultaneous multi-animal ventilation with BiFIV is unexplored.
Purpose of the Study:
- To test the hypothesis that BiFIV can provide simultaneous efficient ventilation for multiple animals using a single ventilator prototype.
- To compare the efficacy of BiFIV with conventional ventilation in a multi-animal model.
Main Methods:
- Three groups of three domestic pigs with normal lung compliance were studied.
- Animals were anesthetized and intubated with a specific multiluminal endotracheal tube.
- Physiological parameters and arterial blood gases were recorded during conventional and BiFIV modes.
Main Results:
- All but one animal survived the experiment.
- No significant differences in arterial gas exchange were observed between BiFIV and conventional ventilation.
- Oxygenation (PaO2) was comparable between groups: 112+/-17 mmHg (conventional) vs. 115+/-16 mmHg (BiFIV).
Conclusions:
- Variable time-cycled tracheal gas insufflation (BiFIV) can efficiently ventilate multiple animals simultaneously with a single device.
- BiFIV demonstrates potential for laboratory use and mass casualty situations, pending validation in pathological models.